9:00 am Welcome
Suzanne Tomlinson-Mathis, Gulf Coast Consortia
Ken Chen, MD Anderson Cancer Center
Moderator: Kristopher Brannan, Houston Methodist Research Institute
9:10-9:50 Keynote Presentation
From Single-Cell Proteomics to Molecular Mechanisms
Nikolai Slavov, Harvard University
9:50-10:20 Vendor Session-Pre-Function and Event Hall
Moderator: Nicholas Navin, MD Anderson Cancer Center
Session 1: Single Cell Analysis in Disease
10:20-10:40 Single-Cell Duplex Sequencing Uncovers Distinct Mutational Dynamics During Clonal Expansion and Novel Therapeutic Vulnerabilities in Breast Cancer
Chenghang Zong, Baylor College of Medicine
10:40-11:00 Molecular Archeology of Cancer
Peter Van Loo, MD Anderson Cancer Center
11:00-11:15 Selected Abstract Talk
Single Cell-level Transcriptomics Reveal Tumor Microenvironment Adaptations in TNBC Metastasis
Eashan Shetty, University of Houston
Moderator: Kristopher Brannan, Houston Methodist Research Institute
11:15-11:50 Lighting poster talks
Determining the Role of 3D Genome Organization in Promoting Tumor Heterogeneity in Glioblastoma Multiforme
Jessica Alsing, Univ. of Texas Medical Branch, Poster 1
Fused in Linear Sequence, but Estranged in 3D – A Philadelphia Chromosome Story
Gabrielle Dewson, Univ. of Texas Medical Branch, Poster 13
A Diet-Sensitive Nuclear Receptor Pathway Modulates Gastric Epithelial Progenitor Cell Differentiation
Margarita Divenko, Baylor College of Medicine, Poster 2
Integrating E-slices with Intact TME with Visium HD for Spatially Resolved Response Assays
Viridiana Leyva-Aranda, Empiri, Poster 3
Inference of Unmeasured Features in Spatial Proteomics Data Using scRNA-seq References
Qingnan Liang, MD Anderson Cancer Center, Poster 4
Profiling Histone Modifications in Single Cells to Gain Insight into the Effects of Epigenetic Drug Treatment on Tumor Cells
Cella Mann, Takara Bio USA, Inc., Poster 21
Multi-omic Single-cell Analysis Reveals TET2 Deficiency Mitigates Transposable Element Upregulation During Hematopoetic Aging
Logan Rivera, Texas A&M College of Medicine, Poster 25
Identifying High Molecular Weight Protein Complexes from Individual Cancer Cells using Open Microfluidics
Edgar Ruiz Bello, Rice Univ., Poster 26
BRAF Treatment Response Determinants in Anaplastic Thyroid Cancer Studied through Single-Cell DNA and RNA Sequencing
Aatish Thennavan, MD Anderson Cancer Center, Poster 5
KMT2D is a Master Epigenetic Regulator of Lineage Plasticity in Lung Squamous Cell Carcinoma
Manrong Wu, Baylor College of Medicine, Poster 6
In Vivo Profiling the Activity of Extracellular Proteases in the Tumor Microenvironment
Yue Xuan, MD Anderson Cancer Center, Poster 7
Coalescing Single Cell Genomes and Transcriptomes to Decode Breast Cancer Progression
Rui Ye, MD Anderson Cancer Center, Poster 8
Single-Cell Analysis Reveals Th17/Th1 Transition Predicts Immunotherapy Success in Gastric Cancer
Liudeng Zhang, MD Anderson Cancer Center, Poster 9
11:50-1:45 Lunch and Poster Session-Event Hall
11:50-12:45 Lunch
12:45-2:00 Posters
Moderators: Ken Chen, MD Anderson Cancer Center
2:00-2:40 Keynote Presentation
Deciphering the Origins and Clonal Evolution of Colorectal Precancers Via Single-Cell Genomics
Ken Lau, Vanderbilt University
Moderators: Guy Nir, University of Texas Medical Branch, Galveston
Gabrielle Dewson, University of Texas Medical Branch, Galveston
Session 2: Integrating Engineered Biological Models with Single-Cell and Spatial Analysis
2:40-3:00
scRNA-seq Guided Identification of a Master Regulator of Gastric Stem Cell Differentiation
Sumimasa Arimura, Baylor College of Medicine
3:00-3:20 Interrogation of Inflammation-associated Intestinal Stem Cell Transformation by Single Cell Analysis
Lan Zhou, Houston Methodist Research Institute
3:20-3:35 Selected Abstract Talk
A Spatial Proteomic Atlas of Desmoplastic Small Round Cell Tumors Reveals Inter- and Intra-tumoral Heterogeneity
Kevin Murgas, MD Anderson Cancer Center
3:35-4:05 Vendor Session-Pre-Function and Event Hall
Session 3: Beyond the Transcriptome
Moderators: Julea Vlassakis, Rice University
V. Mitheera, MD Anderson Cancer Center
4:05-4:25 Integrations Beyond Transcriptomics: Proteomics and 3D Genomics
Ye Zheng, MD Anderson Cancer Center
4:25-4:45 Adding Spatial Context to Single Cell Transcriptomics Identifies Cell-Cell Interactions in Dynamic Tissue Contexts
Ken Hu, MD Anderson Cancer Center
4:45-5:00 Selected Abstract Talk
Cell Type-Resolved Telomere Length Dynamics in Normal and Malignant Breast Epithelium
Nicolaas Baudoin, MD Anderson Cancer Center
5:00-5:05 Closing Remarks and drawing
TBA
5:05-6:00 Reception